Effect of Swietenia macrophylla king and Eriobotrya japonica lindl on clinic biochemistry of hyperglycemic Wistar rats


  • Angélica Barrón Jaime
  • Rubén Montalvo González
  • David Herrera Rosales
  • Eduardo Mendeleev Becerra Verdín
  • Efigenia Montalvo González
  • Roberto Padilla Noriega
  • Ascención Montalvo González
  • Jorge Rafael Figueroa Morales




hypoglycemic agent, Swietenia macrophylla, Eriobotrya japonica, wistar rats


The anti-hyperglycemic activity in ethanolic extracts of mahogany seeds (Swietenia macrophylla king) and medlar leaves (Eriobotrya japonica lindl) have shown to be promising candidates for use in patients with type 2 Diabetes Mellitus due to their high hypoglycemic capacity. In this study, the nutritional composition of the plant material used and a comparison of the effect of ethanolic extracts of mahogany seeds (Swietenia), medlar leaves (Eriobotrya), and metformin on biochemical parameters of hyperglycemic Wistar rats were evaluated. Regarding the nutritional composition, it was found that loquat leaves have a high content of dietary fiber (35 g/100 g bs); while mahogany seed has a good amount of protein (19 %) and lipids (71 %). Swietenia was effective in controlling biochemical parameters of hyperglycemic rats, but at a lower level than metformin. In contrast, Eriobotrya reduced the glucose content, to values without significant differences from the control group in healthy rats. However, the content of cholesterol, triglycerides, and urea; as well as alanine aminotransferase activity, was lower in rats treated with Eriobotrya. In conclusion, both plants are an alternative to control biochemical parameters at normal levels in hyperglycemic individuals.


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How to Cite

Jaime, A. B., González, R. M., Rosales, D. H., Verdín, E. M. B., González, E. M., Noriega, R. P., González, A. M., & Morales, J. R. F. (2024). Effect of Swietenia macrophylla king and Eriobotrya japonica lindl on clinic biochemistry of hyperglycemic Wistar rats. South Florida Journal of Development, 5(2), 580–591. https://doi.org/10.46932/sfjdv5n2-013