Tamoxifen as an effective treatment for refractory mania: a case report


  • Deldhy Nicolas Moya-Sánchez
  • Daniel Escamilla-Diaz
  • José Antonio Gutierrez-Gonzalez
  • Marta Georgina Ochoa-Madrigal
  • Oscar Meneses-Luna
  • Alexia Moya-Sánchez
  • Orlando Lugo-Gálvez
  • Francisco Javier Cruz-Aviña
  • Alejandro Salazar-Rodríguez
  • Sharon Venecia Nuñez-Pichardo
  • Emmanuel Alejandro Chavez-Martinez




bipolar disorder, mania, tamoxifen, Protein Kinase C (PKC), case report


Tamoxifen is a medication that acts as a selective estrogen receptor modulator (SERM) by inhibiting protein kinase C (PKC). It has various effects on different tissues in the body, depending on whether the tissue expresses estrogen receptors. For instance, it can reduce inflammation and neuronal excitability. Several studies have shown that tamoxifen could be effective in treating refractory mania, a type of mania that has shown resistance to mood stabilizers and other treatments. The rationale for its use could be explained by the fact that PKC is an enzyme that seemingly plays a significant role in the genesis of mania. We present the case of a 43-year-old female patient with bipolar disorder, who has had 43 previous hospitalizations and has undergone multiple treatments. Management with tamoxifen was initiated to control the manic episode. 


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How to Cite

Moya-Sánchez, D. N., Escamilla-Diaz, D., Gutierrez-Gonzalez, J. A., Ochoa-Madrigal, M. G., Meneses-Luna, O., Moya-Sánchez, A., Lugo-Gálvez, O., Cruz-Aviña, F. J., Salazar-Rodríguez, A., Nuñez-Pichardo, S. V., & Chavez-Martinez, E. A. (2023). Tamoxifen as an effective treatment for refractory mania: a case report. South Florida Journal of Development, 4(5), 2127–2137. https://doi.org/10.46932/sfjdv4n5-023